The pharmacological value of pomegranate husk-derived polyphenols is determined by the presence of isomeric ellagitannins. Shaanxi Bieyouth Biotech offers standardized separation of Punicalagin A & B to support clean-label formulations worldwide.
Punicalagins are large molecular weight water-soluble ellagitannins ($C_{48}H_{28}O_{30}$) unique to the pericarp of Punica granatum. Biochemically, they exist in two dynamic isomeric configurations: Punicalagin A (alpha) and Punicalagin B (beta). These compounds act as upstream biological precursors that hydrolyze into ellagic acid inside the human digestive tract, which is subsequently converted by intestinal microbiota into gut-rejuvenating metabolites known as Urolithins (Urolithin A, B, C, and D).
Unlike standard antioxidant extracts, Shaanxi Bieyouth Biotech's standardized OEM Punicalagin A/B is engineered for high solubility and metabolic activation. By targeting cellular health via mitophagy—the selective clearance of damaged mitochondria—this polyphenol formulation helps prevent cellular senescence, supports cardiovasculary tissue elasticity, and modulates systemic inflammatory markers via the NF-κB and Nrf2 pathways.
From raw pericarp selection to target chromatography, our extraction processes maintain active molecular integrity and ensure batch-to-batch consistency.
Using green chemistry processes, we utilize pressurized, sub-critical water at optimized temperatures. This extracts hydrophilic Punicalagin A and B isomers without toxic organic solvents like methanol or acetone.
Multi-stage ceramic microfiltration and ultrafiltration separate high molecular weight tannins and pectins from active monomers, preventing cloudiness in final liquid applications.
Every single manufacturing batch undergoes HPLC-DAD verification to guarantee that Punicalagin A + B concentration ranges from 20% up to 40% based on customer specification requirements.
We employ macroporous adsorption resins to clean resin residues, ensuring pesticides, plasticizers, and heavy metals (lead, arsenic, cadmium, mercury) fall well below global regulatory thresholds.
Industrial demand for high-purity Punicalagin A/B is rising rapidly across international markets as manufacturers look to replace generic pomegranate extracts with clinically backed, targeted bioactives.
In mature dietary supplement markets like North America and the European Union, standard pomegranate extracts are losing market share to specialized, standardized ellagitannins. High-purity Punicalagin A/B is increasingly integrated into healthy aging, cardiovascular, and nutricosmetic formulations.
Shaanxi Bieyouth Biotech actively helps clients navigate global regulatory processes. Our facility holds self-affirmed FDA registrations, and we provide comprehensive analytical portfolios containing HPLC chromatograms, heavy metal screenings, microbiological safety files, and stability reports to ensure smooth custom clearance across major global ports.
Tailored biochemical solutions optimized to fit regional product preferences, compliance guidelines, and consumer behavior.
Designed for premium capsules, tablets, and drink mixes targeting mitochondrial health. Formulators pair Punicalagin A/B with NMN, Coenzyme Q10, or Ergothioneine to create synergistic anti-aging and athletic performance solutions.
Meets European demand for clean-label, heart-healthy options. It targets LDL cholesterol oxidation pathways and vascular function, and is designed to fit seamlessly into regulatory frameworks focused on non-synthetic ingredients.
Widely utilized in the Japanese, South Korean, and Chinese cosmetics sectors. Its potent anti-glycation action prevents collagen stiffness, while its UV-recovery properties make it a key ingredient in luxury nutricosmetic beauty drinks.
Strategically located in Shaanxi Province, Shaanxi Bieyouth Biotech utilizes regional raw material access and industrial-scale manufacturing to guarantee supply stability and cost efficiency.
Shaanxi Bieyouth Biotech's production facilities operate under strict cGMP protocols. Located in a major agricultural and chemical extraction hub, we source premium pomegranates locally and maintain control over our entire raw material supply chain. This helps prevent seasonal price fluctuations and guarantees reliable year-round delivery.
Our raw materials undergo thorough testing before entering the extraction line. Advanced water recycling, highly automated counter-current extraction systems, and dedicated spray-drying towers allow us to maximize yield while minimizing energy waste. The result is a high-purity product delivered with fast turnaround times and competitive pricing.
Established in 2018, Shaanxi Bieyouth Biotech Co., Ltd. is a large-scale supplier integrating production, scientific research, and global sales of premium botanical extracts.
We mainly focus on natural plant and animal extracts, food additives, cosmetic raw materials, and high-performance pharmaceutical raw materials. Our production facilities are GMP certified, featuring two standardized production workshops and state-of-the-art extraction machinery. Through years of research and supply-chain optimization, our products are regularly exported to the United States, the United Kingdom, Canada, Russia, Australia, and other global regions.
In August 2020, we established our Institute of Biology to expand research into cosmetic raw materials, a project later named a key regional project in 2022. We hold US FDA registration certificates, ensuring our ingredients meet international safety and distribution standards.
In-depth consultations to define product specifications, purity metrics, desired formulation formats, and target volumes.
We work with client specifications to design unique, stable formulations, leveraging our research institute's expertise.
Producing lab prototypes for physical, chemical, and organoleptic client testing and official approval.
Executing commercial-scale production runs adhering to strict internal QC guidelines and batch recording protocols.
Company founded, establishing local botanical sourcing networks and initial export channels.
Awarded "Integrity Enterprise" and "Quality Assured Enterprise" status by regional trade associations.
Launched direct international sales network and established the Institute of Biology for cosmetic raw material research.
Obtained formal FDA certificate registration, expanding access to North American pharmaceutical and supplement brands.
Participated in the Shanghai International Cosmetics, Personal Care and Home Care Raw Materials Exhibition to showcase new bioactives.
A dedicated, multi-disciplinary team committed to supporting your project from formulation through international logistics.
Global Account Lead
Regulatory Compliance Specialist
R&D Formulation Engineer
Quality Assurance Manager
Bioprocess Engineer
Supply Chain Director
Logistics Coordinator
Answers to common questions regarding extraction specs, stability, logistics, and OEM capabilities.
Bieyouth
