Hesperidin, a natural flavanone glycoside, has emerged as a promising ingredient in skincare for its potent antioxidant and anti-inflammatory properties. Derived primarily from citrus fruits (e.g., oranges, lemons) and their peels, this compound (C₂₈H₃₄O₁₅) has been studied for its ability to address various skin concerns, from pigmentation to vascular health. First identified in citrus extracts, hesperidin is now synthesized and incorporated into dermatological and cosmetic formulations for its therapeutic benefits.