Urolithin A (3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one) is a bioactive metabolite derived from ellagitannins in pomegranates, walnuts, and berries, celebrated for its role in promoting mitochondrial health and cellular rejuvenation. Formed by gut microbiota fermentation, it selectively activates mitophagy—the process of removing damaged mitochondria—thereby enhancing cellular energy production and reducing age-related decline. Backed by preclinical research, Urolithin A is a cornerstone in nutraceutical and anti-aging formulations, trusted for its efficacy in combating cellular senescence.