Reishi mushroom extract is made by timely harvesting and maturing fresh fruiting bodies. After drying, processes such as hot water extraction (or alcohol extraction), vacuum concentration, and spray drying are adopted to obtain Reishi mushroom extract powder, which is the essence of Reishi mushroom extracted by a high multiple concentration of Reishi mushroom powder. Reishi mushroom extract contains more abundant main active ingredients such as Ganoderma lucidum polysaccharides and triterpenoid ganoderic acid than Ganoderma lucidum powder.